Question

The topic is how cancer works?

In general, explain why TKIs are typically given orally whereas monoclonal antibodies are typically given via IV. Which one would you rather take, in your perspective?

TKIs: "Any drug used to treat cancer (including tyrosine kinase inhibitors or TKIs)" TKIs come as pills, taken orally.

IV: Intravenous chemotherapy (IV chemo)

Answer 1

Tyrosine kinase inhibitors (TKIs) are a type of targeted therapy. TKIs come as pills, taken orally. A targeted therapy identifies and attacks specific types of cancer cells while causing less damage to normal cells. In CML, TKIs target the abnormal BCR-ABL1 protein that causes uncontrolled CML cell growth and block its function, causing the CML cells to die.TKIs are taken orally because Oral administration is a route of administration where a substance is taken through the mouth. Per os (P.O.) is sometimes used as an abbreviation for medication to be taken orally. Many medications are taken orally because they are intended to have a systemic effect, reaching different parts of the body via the bloodstream. “Initial” treatment is the first therapy given for a disease. If the first treatment does not work because of intolerance (intolerable side effects) to a particular drug or drug resistance (CML is not responding to the drug) during therapy.

Monoclonal antibodies are given intravenously (injected into a vein). The antibodies themselves are proteins, so giving them directly cause something like an allergic reaction. This is more common while the drug is first being given. Possible side effects can include:

• Fever
• Chills
• Weakness
• Headache
• Nausea
• Vomiting
• Diarrhea
• Low blood pressure

In my perspective i would prefer IV over TKIs because compared with chemotherapy drugs, naked mAbs tend to have fewer serious side effects.Also not all cancers have the same targets. To find the most effective treatment, your doctor may run tests to identify the genes, proteins, and other factors involved in your leukemia. It is important to note that men and women taking TKIs should avoid fathering a child or becoming pregnant while taking the drugs because of a risk to the developing child.