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In: Biology

Explain the Warburg hypothesis. Why and how is it commonly misinterpreted to stop cancer progression by...

Explain the Warburg hypothesis. Why and how is it commonly misinterpreted to stop cancer progression by avoiding sugar?

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Expert Solution

The warburg hypothesis postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria. In other words, instead of fully respiring in the presence of adequate oxygen, cancer cells ferment.
Warburg effect links the high rate of glucose fermentation to cancer. Together with glutamine, glucose via glycolysis provides the carbon skeletons, NADPH, and ATP to build new cancer cells, which persist in hypoxia that in turn rewires metabolic pathways for cell growth and survival.
Sugar feeds every cell of our body so intake of sugar is progressing the cancer cell also . so stop intake of sugar is also helps to reduce progression of cancer cell .


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