Given a protein localization pathway, make predictions about disruption of the pathway. Can you give me...

Given a protein localization pathway, make predictions about disruption of the pathway.

Can you give me some examples?

Expert Solution

1. Localization of Protein Kinase A (PKA) via A-Kinase Anchoring Proteins (AKAP) is important for cAMP responsiveness in many cellular systems and evidence suggests that AKAPs play an important role in cardiac signaling.

Disruption of PKA localization with TAT-AKAD ( cell permeable peptide, which scientist have termed TAT-AKAD for TAT-conjugated A-Kinase Anchoring Disruptor) had negative effects on chronotropy, inotropy and lusitropy, thereby indicating a key role for AKAP-targeted PKA in control of heart rate and contractile function.(Hemal et al;2010)

2. Refere figure for another example.(Reference: Hamidesh et al;2017)

gladiator answered 2 years ago

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