IBMX is isobutyl methyl xanthine, one of several modified xanthines (purines) that act as phosphodiesterase inhibitors....

IBMX is isobutyl methyl xanthine, one of several modified xanthines (purines) that act as phosphodiesterase inhibitors. How and where would IBMX effect the PKA pathway?

Expert Solution

PKA pathway is called Protein kinase A pathway in which Protein kinase A is activated by the Cyclic Adenosine Monophosphate (cAMP). Four molecules of cAMP activates PKA. The activated PKA helps in the phosphirylation of serine and threonine in phosphoprotein synthesis and many other metabolic pathways.

This cAMP is cleaved by phosphodiesterase results in the ihibition of PKA pathway.

As Isobutyl methyl xanthine (IBMX) is a inhibitor of Phosphodiesterase which results in the cAMP available. Thus the available cAMP is used for the activation of PKA in PKA pathway.

Thus at the secondary messenger IBMX plays an important role in activation of Protein kinase A (PKA) pathway.

gladiator answered 6 months ago

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