Question

Aspirin overdose has been shown to cause hyperventilation in men, resembling the toxic effects of pesticides and herbicides like DDT and dinitro phenol. The mechanism of action has been shown to involve the electrochemical gradient across the mitochondrial inner membrane. Explain how these compounds can affect the aforementioned gradient and how that effect is connected to the symptom of hyperventilation.

Answer 1

Hyperventilation is the condition were the carbon dioxide  levels are low that can lead to narrow the blood vessels that supply blood to brain and by reduction of the blood supply in the brain leads to severe  hyperventilation, In some cases it occurs very rare and in some cases it leads to depression, anger and anxiety. As mitochondria is a power house of the cell the tissue and organ functions are purely dependent on the  production of ATP and especially when the demand of energy is high. Mitochondria also have important biochemical pathways that include apoptosis and detoxification of the reactive oxygen species and intracellular calcium regulation lipid metabolism. Most of the environmental toxins that can occupational exposure to toxic chemicals such as herbicides, pesticides and phthalates incur increases the health risks and causes damage to the respiratory passage of air which leads to hyperventilation. The main disorder of mitochondrial bioenergetics or also called Primary Mitochondrial Diseases (PMD) are due to inherited genetic disorders that can be seen in the nuclear of mitochondrial genomes which result in defective capacity of oxidative phosphorylation and the production of cellular energy.