What is LTP? What are some of the presynaptic changes observed? What are some of the...

What is LTP?
What are some of the presynaptic changes observed?
What are some of the postsynaptic changes observed?
How do the AMPA and NMDA glutamate receptors contribute to LTP?

Expert Solution

LTP mean long term Potentiation. It is the persistent strengthening of a synaptic connection. It may work for a minute or hours .It induce may due to strong tetanic stimulation to synapse. LTP is the primary mechanism of learning and memory.

Some Presynaptic change

Increase or decrease in neurotransmitter release occur during presynaptic stage.
Change in synaptic strength occur
Rapid signal at axon terminal

Some postsynaptic change

Modification in receptor or biophysical properties
Addition of AMPA channel to the synapse in large group
Change in the mode of glutamate release
AMPA channel addition to extra synaptic membrane and diffusion equilibrium of extra synaptic membrane with receptor of synapse

AMPA and NMDA are the two receptor that is important in point of view of LTP. The AMPA receptor is paired with an ion channel so that when glutamate binds to this receptor , this channel allow sodium ions to enter the post synaptic neuron.

Hope I fully explain your doubt. Thank You

gladiator answered 7 months ago

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