Question

Beginning with sensitisation, describe the immune events that you expect to take place following the transplantation of a kidney between nonidentical siblings who share half their MHC molecules. You can assume that they are matched for ABO blood group antigens and have successfully passed the cross-match (i.e., they are antibody negative in a cross-match test).

What is the biologic basis for attempting to use soluble CTLA-4Ig or anti-CD40L to block allograft rejection?

Answer 1

Answer:

According to the hypothesis, the immuno-suppressive agents like CTLA-4Ig or anti-CD40L are used in this case. The biological events occur during kidney transplantation that is immuno suppression. The mechanism occurs in immunological rejection of the organ through T cells - dependent mechanism. When these immuno-suppressive agents administered the function of T cells was suppressed, thereby blocks cytokines activation mainly IL-2 (cytokines which is responsible for signaling immune system) for prolonged periods until kidney transplantation is completed.

The general compatible pairs which can easily transplanted with out using any immunosuppressive agents:

A blood test is used to determine, if the donor is match and marked with color:

1. A (DONOR) female ------               B (RECIPIENTS) male - is not suited (incompatible pair)

2. B (DONOR) female   ------              A (RECIPIENTS) female is not suited (incompatible pair)

3. A (DONOR) female   ------              A (RECIPIENTS) female - is suitable (compatible pair)

4. B (DONOR) female   ------              B (RECIPIENTS) male - is suitable (compatible pair)

Multiple donor / patient pairs is compatible for donating and receiving kidney:

1. A (DONOR) female    ------             A (RECIPIENTS) female - is suitable (compatible pair)

2. B (DONOR) female   ------              B (RECIPIENTS) male - is suitable (compatible pair)

3. O (DONOR) female   ------              A (RECIPIENTS) male - is suitable (compatible pair)

4. O (DONOR) male    ------                O (RECIPIENTS) female- is suitable (compatible pair)

5. B (DONOR) female    ------              B (RECIPIENTS) male- is suitable (compatible pair)

6. B (DONOR) male    ------                 AB (RECIPIENTS) male- is suitable (compatible pair)

Note: The provided answer is as per my knowledge may be or may not be 100% correct, but definitely relevant to your question thank you so much.