Question

In: Biology

Prodrugs: a. What are the attributes of a good prodrug? b. Cite 4 examples of marketed...

Prodrugs:

a. What are the attributes of a good prodrug?

b. Cite 4 examples of marketed prodrugs?

Solutions

Expert Solution

ANSWER:

Attributes of a Good Prodrug:

An ideal prodrug are expected to feature the following properties:

  • Have an appreciable chemical stability across a pH Range (stability at physiological pHs).
  • Weak (or no) activity against any pharmacological targets.
  • Adequately high aqueous solubility and passive permeability.
  • The released carrier is non-toxic (have no unwanted pharmacological effects).
  • Have resistance to the process of hydrolysis during the phase of absorption.
  • High transcellular absortion.
  • Post-absorption, rapid and quantitative breakdown to yield parent (active) components.

Examples for marketed Prodrugs:

  • Fospropofol (Anaesthetic)
  • Lansoprazole (proton pump inhibitors)
  • Valacyclovir (antiviral)
  • Nepafenac (anti-inflammatory)

other examples may include dabigatran etexilate (approved in 2010), isavuconazonium (2015), selexipag (2015), latanoprostene bunod (2017), benzhydrocodone (2018) etc

gladiator answered 2 years ago
Next > < Previous

Related Solutions

a) Give 5 good examples of Regular language. b) Give 5 good examples of Regular Grammar.
a) Give 5 good examples of Regular language. b) Give 5 good examples of Regular Grammar.
Cite 4 Expectations of Employee from Management? Give Examples for each expectation., Comprehensive
Cite 4 Expectations of Employee from Management? Give Examples for each expectation., Comprehensive
Is there sometimes a conflict between good economics and good politics? Cite an example of such...
Is there sometimes a conflict between good economics and good politics? Cite an example of such an issue.
Concept Map: Diversity of capacitor types used in electronics. To Do: 1) Cite 4 examples of...
Concept Map: Diversity of capacitor types used in electronics. To Do: 1) Cite 4 examples of capacitor’s use in electronics. 2) What type of capacitor is each of the 4 you cite? Suggest how each is manufactured
QUESTION 1 System Components include entities, attributes and resources. Cite an example of these components for...
QUESTION 1 System Components include entities, attributes and resources. Cite an example of these components for the gives systems Type of System Entities Attributes Resources Bus System Communications Barbershop System                                                                                    (UN,9) (b) A random variable X has a probability mass function defined by                                      PX=x=kx-1,                   if x=2, 3k8-x,               if x=4, 5, 6            0                         otherwise             i) Write out the probability mass function of X.                              ii) Find the expectation of (2X).                                                      iii)...
QUESTION 1 System Components include entities, attributes and resources. Cite an example of these components for...
QUESTION 1 System Components include entities, attributes and resources. Cite an example of these components for the gives systems Type of System Entities Attributes Resources Bus System Communications Barbershop System    (b) A random variable X has a probability mass function defined by        i) Write out the probability mass function of X.                              ii) Find the expectation of (2X).                                                      iii) Find the variance of X.                      iv) Find P(2≤X≤5) v)  Find P(X≥5)
What are 3 examples of how statistics can be used in daily life and cite the...
What are 3 examples of how statistics can be used in daily life and cite the different statistics concepts that apply to those examples?
1.What are at least three attributes of a good sample when it comes to assessment characteristic...
1.What are at least three attributes of a good sample when it comes to assessment characteristic and making predictions about the actions of populations 2. what factors contributes to the wealth gap between blacks, whites and women
1.What are the attributes of a good project manager? and how would you suggest the project...
1.What are the attributes of a good project manager? and how would you suggest the project manager should typically deal with the challenge of building a high-performance project team?
What are the attributes of a good quantitative analysis model? C.W. Churchman once said that "mathematics...
What are the attributes of a good quantitative analysis model? C.W. Churchman once said that "mathematics tends to lull the unsuspecting into believing that he who thinks elaborately thinks well." Do you think that the best QA models are the ones that are most elaborate and complex mathematically? Why or why not?
ADVERTISEMENT
Subjects
ADVERTISEMENT
Latest Questions
ADVERTISEMENT