Question

In: Biology

Why are cyclin-dependent kinases such hot targets for cancer therapy?

  1. Why are cyclin-dependent kinases such hot targets for cancer therapy?

Solutions

Expert Solution

Cell cycle checkpoints are the regulatory points where the events occurring in cell cycle are checked and the transition to next stage of the cell cycle is controlled. This is done with the help of special proteins called cyclins. The amount of these proteins increase and decrease in every stage. These proteins are responsible for activating enzymes called as cyclin-dependent kinase. These enzymes are responsible for phosphorylation of cell cycle control proteins and therefore control the transition to next stages of cell cycle.

Cancer cells are the cells which have the ability to divide uncontrollably. They keep on replicating even if there is any damage in the cell. This damage occurs because these cells do not respond to cyclins and cyclin dependent kinases. If there is a mutation in gene encoding for cycling and cyclin dependent kinases, then the control over cell cycle is lost and this results in the formation of cancerous cells.

Please rate high.


Related Solutions

Give an example of when hot therapy should be used and why Give an example of...
Give an example of when hot therapy should be used and why Give an example of when cold therapy should be used and why. i post this two question three days ago they give me the example but there was no answer why please  can you say why the example used for the hot therapy and why for the cold therapy i don' t need just example i want to know why too
Suppose that a mammalian cell line is heterozygous at the sole locus encoding the cyclin dependent...
Suppose that a mammalian cell line is heterozygous at the sole locus encoding the cyclin dependent kinase of MPF. One allele encodes Active CdK, the other allele harbors a nonsense codon. Now, in one cell, a mutation occurs that introduces a frame shift into the active copy of this Cdk? What happens with this mutated cell? It divides on It gets stuck in G2 It gets stuck in G1 It gets stuck in S phase
Why is a drug that inhibits telomerase not a good choice for cancer therapy? Make sure...
Why is a drug that inhibits telomerase not a good choice for cancer therapy? Make sure to explain what telomerase does in a normal healthy cell.
You are working in the cancer therapy division of a hospital. This hospital treats cancer by...
You are working in the cancer therapy division of a hospital. This hospital treats cancer by hitting a tumor with high energy protons from a cyclotron. When the protons leave the cyclotron they are going at half the speed of light. You are in charge of deflecting the protons so they hit the patent's tumor. This deflection is accomplished by passing the proton beam between two flat, parallel electrodes that have a length of 10.0 feet in the entering beam...
Which of the following is not true about cyclin-dependent kinase (CDK): a. It’s present only during...
Which of the following is not true about cyclin-dependent kinase (CDK): a. It’s present only during the M phase of the cell cycle b. When CDK is combined with cyclin, the MPF (Mitosis Promoting Factor) formed initiates mitosis c. It’s a protein that controls other proteins using phosphate groups d. It’s present at all times during the cell cycle
What sorts of mutational changes could occur in a gene for a cyclin-dependent kinase might lead...
What sorts of mutational changes could occur in a gene for a cyclin-dependent kinase might lead to a cell becoming cancerous? Be as specific as you can as to what effect the mutational change would have on the kinase protein.
Describe two proteins phosphorylated by the M phase cyclin-dependent kinase (M-Cdk). What does the phosphorylation of...
Describe two proteins phosphorylated by the M phase cyclin-dependent kinase (M-Cdk). What does the phosphorylation of that protein cause?
In general, how does the immune system respond to cancer?   4.    Why does radiation therapy often lead...
In general, how does the immune system respond to cancer?   4.    Why does radiation therapy often lead to hair loss and skin problems? 5.    Discuss the use of non-steroidal anti-inflammatory drugs (NSAIDS) in the treatment of chronic pain 6.  Describe several ways cancer/cancer cells evade the immune system 7. In the past decade, many investigations recorded heightened interest in immunotherapy              a. What is immunotherapy?    b.   Imagine you are an immunologist presented with the task of using immunotherapy for Dexter’s                  cancer.   Devise an experimental...
1a. Why are some cells targets for a certain hormone and others are not targets? 1b....
1a. Why are some cells targets for a certain hormone and others are not targets? 1b. What is a hormone? 2. What 3 categories of things does the Pituitary gland do? 3. How does the pituitary affect the function of certain endocrine glands? 4. Why are endocrine glands called "ductless" 5. What is the function of the thyroid hormone? 6. What is the function of melatonin? 7. How does insulin function? 8. What two hormones are produced by the adrenal...
using a diagram that illustrates the relevant therapeutic targets for anti-coagulant therapy, locate the specific target...
using a diagram that illustrates the relevant therapeutic targets for anti-coagulant therapy, locate the specific target for each of the following: Warfarin, LMW Heparin, Aspirin, Clopidogrel
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT