Why are cyclin-dependent kinases such hot targets for cancer therapy?

Why are cyclin-dependent kinases such hot targets for cancer therapy?

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Expert Solution

Cell cycle checkpoints are the regulatory points where the events occurring in cell cycle are checked and the transition to next stage of the cell cycle is controlled. This is done with the help of special proteins called cyclins. The amount of these proteins increase and decrease in every stage. These proteins are responsible for activating enzymes called as cyclin-dependent kinase. These enzymes are responsible for phosphorylation of cell cycle control proteins and therefore control the transition to next stages of cell cycle.

Cancer cells are the cells which have the ability to divide uncontrollably. They keep on replicating even if there is any damage in the cell. This damage occurs because these cells do not respond to cyclins and cyclin dependent kinases. If there is a mutation in gene encoding for cycling and cyclin dependent kinases, then the control over cell cycle is lost and this results in the formation of cancerous cells.

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gladiator answered 1 year ago

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