In: Biology
|
Adapters (structure) |
PAMPs/Activators |
Species |
|
---|---|---|---|---|
TLR |
TLR1–TLR2 (LRR–TIR) |
MyD88 (TIR–DD), TIRAP (TIR) |
Triacyl lipopeptides |
Bacteria |
TLR2–TLR6 (LRR–TIR) |
MyD88 TIRAP |
Diacyl lipopeptides |
Mycoplasma |
|
LTA |
Bacteria |
|||
Zymosan |
Fungus |
|||
TLR2 (LRR–TIR) |
MyD88, TIRAP |
PGN |
Bacteria |
|
Lipoarabinomannan |
Mycobacteria |
|||
Porins |
Bacteria (Neisseria) |
|||
tGPI-mucin |
Parasites (Trypanosoma) |
|||
HA protein |
Virus (Measles virus) |
|||
TLR3 (LRR–TIR) |
TRIF (TIR) |
dsRNA |
Virus |
|
TLR4 (LRR–TIR) |
MyD88, TIRAP, TRIF, TRAM (TIR) |
LPS |
Bacteria |
|
Envelope proteins |
Virus (RSV, MMTV) |
|||
TLR5 (LRR–TIR) |
MyD88 |
Flagellin |
Bacteria |
|
TLR7 (LRR–TIR) |
MyD88 |
ssRNA |
RNA virus |
|
hTLR8 (LRR–TIR) |
MyD88 |
ssRNA |
RNA virus |
|
TLR9 (LRR–TIR) |
MyD88 |
CpG DNA |
Bacteria |
|
DNA |
DNA virus |
|||
Malaria hemozoin |
Parasites |
|||
mTLR11 (LRR–TIR) |
MyD88 |
Not determined |
Bacteria (uropathogenic bacteria) |
|
Profilin-like molecule |
Parasites (Toxoplasma gondii) |
|||
NALP1/NLRP1 (CARD–FIND–NBD–LRR-PYD) |
ASC |
Anthrax lethal toxin |
Bacteria |
|
IPAF/NLRC4 (CARD–NBD–LRR) |
Flagellin |
Bacteria |
||
NAIP5 (BIRx3–NBD–LRR) |
Flagellin |
Bacteria |
||
CLR |
Dectin-1 (lectin–ITAM) |
?-Glucan |
Fungi |
|
RLR |
RIG-I (CARDx2–helicase) |
IPS-1 (CARD) |
RNA (5’-PPP ssRNA, short dsRNA) |
Virus |
MDA5 (CARDx2–helicase) |
IPS-1 |
RNA (poly IC, long dsRNA) |
Virus |
|
LGP2 (helicase) |
RNA |
Virus |
||
NLR |
NOD1/NLRC1 (CARD–NBD–LRR) |
RICK (CARD), CARD9 (CARD) |
iE-DAP |
Bacteria |
NOD2/NLRC2 (CARDx2–NBD–LRR) |
RICK, CARD9 |
MDP |
Bacteria |
|
NALP3/NLRP3 (PYD–NBD–LRR) |
ASC (PYD–CARD) CARDINAL (PYD–FIND) |
MDP |
Bacteria |
|
RNA |
Bacteria, Virus |
|||
ATP |
Bacteria? Host? |