Question

Find all possible pathogen associated molecular patterns (PAMPs) and their respective sensors as a table, including cell surface endosomal cytosolic sensors of PAMPs. Include human and mouse in your table. (YOU SHOULD MENTION TLR, NLR, CLR, and RLR)!!!

Answer 1

PRRs (structure)		Adapters (structure)	PAMPs/Activators	Species
TLR	TLR1–TLR2 (LRR–TIR)	MyD88 (TIR–DD), TIRAP (TIR)	Triacyl lipopeptides	Bacteria
	TLR2–TLR6 (LRR–TIR)	MyD88 TIRAP	Diacyl lipopeptides	Mycoplasma
			LTA	Bacteria
			Zymosan	Fungus
	TLR2 (LRR–TIR)	MyD88, TIRAP	PGN	Bacteria
			Lipoarabinomannan	Mycobacteria
			Porins	Bacteria (Neisseria)
			tGPI-mucin	Parasites (Trypanosoma)
			HA protein	Virus (Measles virus)
	TLR3 (LRR–TIR)	TRIF (TIR)	dsRNA	Virus
	TLR4 (LRR–TIR)	MyD88, TIRAP, TRIF, TRAM (TIR)	LPS	Bacteria
			Envelope proteins	Virus (RSV, MMTV)
	TLR5 (LRR–TIR)	MyD88	Flagellin	Bacteria
	TLR7 (LRR–TIR)	MyD88	ssRNA	RNA virus
	hTLR8 (LRR–TIR)	MyD88	ssRNA	RNA virus
	TLR9 (LRR–TIR)	MyD88	CpG DNA	Bacteria
			DNA	DNA virus
			Malaria hemozoin	Parasites
	mTLR11 (LRR–TIR)	MyD88	Not determined	Bacteria (uropathogenic bacteria)
			Profilin-like molecule	Parasites (Toxoplasma gondii)
	NALP1/NLRP1 (CARD–FIND–NBD–LRR-PYD)	ASC	Anthrax lethal toxin	Bacteria
	IPAF/NLRC4 (CARD–NBD–LRR)		Flagellin	Bacteria
	NAIP5 (BIRx3–NBD–LRR)		Flagellin	Bacteria
CLR	Dectin-1 (lectin–ITAM)		?-Glucan	Fungi
RLR	RIG-I (CARDx2–helicase)	IPS-1 (CARD)	RNA (5’-PPP ssRNA, short dsRNA)	Virus
	MDA5 (CARDx2–helicase)	IPS-1	RNA (poly IC, long dsRNA)	Virus
	LGP2 (helicase)		RNA	Virus
NLR	NOD1/NLRC1 (CARD–NBD–LRR)	RICK (CARD), CARD9 (CARD)	iE-DAP	Bacteria
	NOD2/NLRC2 (CARDx2–NBD–LRR)	RICK, CARD9	MDP	Bacteria
	NALP3/NLRP3 (PYD–NBD–LRR)	ASC (PYD–CARD) CARDINAL (PYD–FIND)	MDP	Bacteria
			RNA	Bacteria, Virus
			ATP	Bacteria? Host?