Question

Rank the species below in terms of suitability as a model system for studying critical aspects of human biology, (1=most preferred, 5=least preferred). Note that all five have been used to study human disease. Explain why you made the choices you did.

Dog

Rhesus monkey             

Mouse               

Chimpanzee            

Armadillo

Answer 1

1. The most preffered model organism is mouse. Mice are biologically very similar to humans and get many of the same diseases, for the same genetic reasons. Mice can be genetically manipulated to mimic virtually any human disease or condition. handling with mouse is easier compared to other and we get faster results. as their size is small so that we can experiment more.

2. Rhesus monekey/ old world monkey, as this very much distinct from human compared to chimpanzee. but they are important for study of human disease due to its genetic, physiologic and metabolic similarity to humans.

3. Chimpanzees are rarely used in research and are protected from highly invasive procedures.As our closest relatives, chimpanzees have a lot of potential to tell us about mechanisms of disease (and what genes may be responsible for human intelligence)

4. armadillo  has been most exploited as a model for leprosy

5. Dog being an important animal model for human genetic disease. In recent years, especially since the sequencing of the canine genome.

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