Question
In: Biology
Sexually reproducing organisms use a variety of strategies to compensate for the gene dosage differences arising from different numbers of X-chromosomes present in males and females.
Sexually reproducing organisms use a variety of strategies to compensate for the gene dosage differences arising from different numbers of X-chromosomes present in males and females. Please describe how dosage compensation of X-chromosome is achieved in mice and Drosophila?
Solutions
Expert Solution
In MICE Dosage compensation is achieved by inactivation of 1X chromosome in homogametic sex(XX)
In Drosophila Dose compensated by hyperactivation of X chromosome in male ( Male specific lethal gene produces Msl proteins in males.Msl proteins are involved in euchromatization of X chromosome.In females Sexlethal proteins Synthesized which target transcript of Sxl genes,tra genes and Msl gene.Sxl proteins blocks Msl 2 mRNA translation so in females msl2 protein absent .
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