9. How does p53 act to regulate the cell cycle?

Expert Solution

gladiator answered 2 years ago

What role does p53 play in mediating cell cycle arrest for cells with DNA damage? How...

What role does p53 play in mediating cell cycle arrest for cells with DNA damage? How is p53 activated?

• Know-how p53 is activated during the cell cycle and what two outcomes are possible –...

• Know-how p53 is activated during the cell cycle and what two outcomes are possible – know the signaling pathways (you do not have to know how PUMA induces apoptosis, just that it does) • Know the types of chemical modulators of receptors – agonist/antagonist • Know the G-protein-linked signaling pathway – how it is activated and what happens downstream – be able to describe the signaling pathways that lead to PKA and PKC activation • Know the tyrosine-kinase signaling...

Understand how proteins that regulate the cell cycle can be altered (due to DNA mutation) and...

Understand how proteins that regulate the cell cycle can be altered (due to DNA mutation) and may lead to cancer (uncontrolled cell division). Know the role of tumor-suppressor genes and proto-oncogenes (genes are DNA segments).

How does a cell regulate protein concentration to impact mechanisms/cell functions? Why is this important? and...

How does a cell regulate protein concentration to impact mechanisms/cell functions? Why is this important? and be able to explain 3-4 ways.

Mismatch Repair: When does it act? ["S phase", "Any time in the cell cycle"] ...

Mismatch Repair: When does it act? ["S phase", "Any time in the cell cycle"] What is fixed? ["Substitutions", "strand breaks", "thymine dimers"] What is removed? ["One bond", "One nitrogenous base", "One nucleotide", "Many nucleotides"] Found in Bacteria? ["Yes", "No"] Found in humans? Base Excision Repair: When does it act? ["S phase", "Any time in the cell cycle"] What is fixed? ["Substitutions", "strand breaks", "thymine dimers"] What is removed? ["One...

What purpose does CDKN1A serve in the cell? What role does it play with p53?

What is the cell cycle and how does the cell move through the different phases of...

What is the cell cycle and how does the cell move through the different phases of the cell cycle? A complete answer will describe the phases and the molecular mechanisms that allows cells to progress from one phase to another.

Describe how positive and negative controls regulate the cell cycle. Your response should include a definition...

Describe how positive and negative controls regulate the cell cycle. Your response should include a definition of positive and negative control, and an example of each

Describe the sequence of the ovarian cycle. How do hormones regulate the cycle?

Anti injunction act vs the constitution act: Does congress have the power to mandate and regulate...

Anti injunction act vs the constitution act: Does congress have the power to mandate and regulate things, such as health insurance based on the interstate commerce clause if the penalty is a tax? Are individual mandates, inner state commerce and medicare expansion unconstitutional?

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