What is Para-Aminobenzoic acid? Give the brief explanation of Para-Aminobenzoic acid.

Expert Solution

Para-Aminobenzoic acid:

History:

Ansbacher demonstrated that depigmentation of the hair (achromotrichia) in mouse could be cured by feeding rice polishings or by adding p-aminobenzoic acid (PABA) to the diet.
PABA also appeared essential for the growth of rat and chick and also for bacterial multiplication.

Occurrence:

PABA is widely distributed in nature.
The good sources are liver, yeast, rice bran and whole wheat.
PABA occurs in conjugated form as a part of folic acid and its derivatives.

Properties:

PABA is a white crystalline substance.
It is sparingly soluble in cold water but freely soluble in hot water and alcohol.

Metabolism:

Woods, for the first time, observed that PABA blocks the bacteriostatic properties of sulfanilamide.
PABA is synthesized from shikimic acid via chorismic acid.

Deficiency:

The deficiency of PABA affects adversely the growth and the maintenance of a normal fur coat in rats.

Human requirements:

There is, at present, no evidence that PABA is an essential dietary factor for man.

Para-Aminobenzoic acid:

Para-aminobenzoic acid is abbreviated as PABA.
It is a natural substance.
It is sometimes called vitamin Bx, but it is not a true vitamin.
It is often used in sunscreen products.

Suhasini Buddi answered 2 years ago

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