Question

Which of the following are true about transition state analogs?

Group of answer choices

They are molecules.

[ Choose ]FALSETRUE

They are enzymes.

[ Choose ]FALSETRUE

They fit in the active site of the target enzyme.

[ Choose ]FALSETRUE

They bind less tightly than the substrates of the normal enzyme-catalyzed reaction.

[ Choose ]FALSETRUE

They bind more tightly than the products of the normal enzyme-catalyzed reaction.

Answer 1

Sol.

1. True.

Transition state analogs (transition state analogues), are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme-catalyzed chemical reaction.

2. False

Transition state analog. ... Transition state analogs can be used as inhibitors in enzyme-catalyzed reactions by blocking the active site of the enzyme. Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate.

3. True

Transition state analogs typically bind to enzyme active sites much more tightly than substrate analogs because the enzyme binds the substrate in the transition state more strongly than one in the ground state, as explained by the thermodynamic cycle as previously described.

4. True

Transition state analogs can be used as inhibitors in enzyme-catalyzed reactions by blocking the active site of the enzyme. Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate.

5. True

Transition state analogs mimic this high energy intermediate but do not undergo a catalyzed chemical reaction and can therefore bind much stronger to an enzyme than simple substrate or product analogs.