Explain the molecular processes occurring inside a transcription bubble

Expert Solution

The transcription bubble is the area of DNA that opens up for the formation of mRNA when the RNA polymerase binds with the DNA. The molecular processes that take place in the transcription bubble are:

1. Binding of sigma factor to the promoter region which initiates the subsequent binding of RNA polymerase that initiates the helicase to open up the DNA structure and also the topoisomerases to stabilise the DNA.

2. Once the RNA polymerase reaches the transcription bubble, the sigma factor along with initiation factors are released.

3. Then elongation factors come and attach to the site of transcription and mRNA is being transcribed from the DNA.

4. Once the mRNA is fully formed from the transcription bubble, termination of the transcription occurs either by rho dependent or rho independent processes. Finally RNA polymerase is released from the transcription bubble and the DNA gets back to its normal double helical structure.

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gladiator answered 1 year ago

Explain the molecular processes occurring inside a transcription bubble.

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