Describe how the different enzyme subunits of pyruvate dehydrogenase interact with their cofactors to catalyze decarboxylation...

Describe how the different enzyme subunits of pyruvate dehydrogenase interact with their cofactors to catalyze decarboxylation of pyruvate.

Expert Solution

gladiator answered 1 year ago

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors...

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors (a) thiamine pyrophosphate; (b) nicotine adenine dinucleotide (NAD+); (c) acetylCoA; (d) flavin adenine dinucleotide (FAD); and (e) lipoamide participate at various steps of the reaction. Explain the role of each cofactor in this reaction. You must use the chemical structures and electronic properties of the intermediates to justify your answers.

The pyruvate dehydrogenase complex utilizes 5 cofactors: for the listed cofactors describes briefly what its role...

The pyruvate dehydrogenase complex utilizes 5 cofactors: for the listed cofactors describes briefly what its role is. 1. ATP 2. Lipoic acid 3.HSCoA 4.FAD 5. NAD+

Can someone explain the role of the three subunits of the pyruvate dehydrogenase complex? Like how...

Can someone explain the role of the three subunits of the pyruvate dehydrogenase complex? Like how those subunits help with the complex turnign pyruvate into acetyl coA? Also why and how does the pyruvate move from cytoplasm to mitochondria? Also why does the Krebs cycle not accept pyruvate? Why does it need to be turned into acetyl coA first?

why is pyruvate dehydrogenase the regulated enzyme of pdc but not dihydrolipoyl transacetylase or dihydrolipoyl dehydrogenase?...

why is pyruvate dehydrogenase the regulated enzyme of pdc but not dihydrolipoyl transacetylase or dihydrolipoyl dehydrogenase? what causes defective regulation of pdc? if cells have energy, it will not run PDC instead what will it run?

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase...

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase Citrate Synthase None of the above Jenny’s lungs have an intrapulmonic pressure of 762 mmHg and an intrapleural pressure of 757 mmHg. Atmospheric pressure is 759 mmHg. What is happening to Jenny? Jenny is inhaling Jenny’s ventilation is at a rest Jenny is exhaling Jenny is suffocating None of the above Which of the following enzymes does ubiquinone transport electrons to in the ETC?

Discuss the following enzymes: hexokinase, pyruvate dehydrogenase, ATP synthase and phosphofructokinase. -How do these enzymes interact...

Discuss the following enzymes: hexokinase, pyruvate dehydrogenase, ATP synthase and phosphofructokinase. -How do these enzymes interact with their substrates and catalyze reactions? -What is unique about each type of enzyme and why are each of the enzymes suited to the specific reactions which they catalyze including major points of regulation (enzyme catalysis, the mechanism of interaction of enzymes with their substrates and the effect of regulators/inhibitors on enzymes)? -What is the organization of the active site for each enzyme? Are...

Pyruvate Dehydrogenase is a huge multi-enzyme complex in which substrates are channeled from one enzyme to...

Pyruvate Dehydrogenase is a huge multi-enzyme complex in which substrates are channeled from one enzyme to the next. In fact, recent evidence suggests that many citric acid cycle enzymes may interact pass substrates along the pathway and that the components of the electron transport chain associate into an electron transfer super complex. What are the advantages of such an arrangement?

Compare the Pyruvate Dehydrogenase Complex to the Branched Chain Ketoacid Dehydrogenase Complex. How are they similar...

Compare the Pyruvate Dehydrogenase Complex to the Branched Chain Ketoacid Dehydrogenase Complex. How are they similar and different in terms of functionality and nutrient requirements l. What organic acids are elevated when there is insufficient activity of the Pyruvate Dehydrogenase Complex (PDC) vs the Branched Chain Ketoacid Dehydrogenase Complex (BCKDC)? (Make sure to understand the difference between BKCDC and BCAA transaminase. These are two completely different enzymes in the BCAA degradation pathway) 1 point

Pyruvate stands at a metabolic crossroad. Describe how pyruvate is converted into four different products.

2. a. explain how a mutation in pyruvate dehydrogenase kinase that increases the enzymes Km will...

2. a. explain how a mutation in pyruvate dehydrogenase kinase that increases the enzymes Km will affect the activity of the complex pyruvate dehydrogenase? b. explain how pyruvate dehydrogenase complex is controlled during physical activity by PDP? c. how can a mutation that affects the binding sight of calcium ions on the pdp enzyme affect the activity of phosphatase enzyme? and how is it likely to affect pdc during physical activity?

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