Question

1-Which of the following is true for ranolazine?

It inhibits late I Na, reduces intracellular sodium and calcium overload, thereby improving diastolic function

It can also be used in treating arrhythmia

It is one of the first line agents for treating unstable angina due to its unique mechanism of action

2-Amiloride: (check one or more)

Prevents potassium from leaving the body

Is an aldosterone antagonist

Has a mild diuretic effect

Works in the ascending limb of the loop of Henle

Answer 1

Answer to 1st question: option A

The Ranolazine drug which inhibits the late inward sodium levels which results in decreasing sodium levels intracellualr and also decreases the intracellular calcium levels in the sodium- calcium exchanger and it leads to relaxation of myocardium and diastolic function also improves. This drug can reverse the action of diastolic dysfunction and improves relaxation.

other options are wrong.

--The Ranolazine drug also cannot be used for the treatment of all cases of Arrhythmia but especially in case of ventricular arrhythmia this drug used to treat.

-- Ranolazine drug is not the one of the first line agents for treating unstable angina due to its unique mechanism of action and usually it can be used as second line agent to treat in those first line agents like calcium channel agents fail to treat angina .

Answer to 2nd question: option A,C

Amiloride is the potassium sparing diuretic in which it restricts the potassium levels from the body and keeps the potassium amount in the body.

--amiloride has mild diuretic effect so it always used in the combination of thiazide to treat the symptoms in the patients.

other options are wrong

--option B is wrong that amiloride is not the aldosterone antagonist because the aldosterone antagonist has weak diuretic properties and used only to treat heart failure and blood pressure.

--option D is wrong that amiloride is works in the distal tubule and collecting duct. The loop diuretics works in the ascending limb of the loop of the henle.