1-A patient will start using clopidogrel. Which of the following is true for this drug: It...

1-A patient will start using clopidogrel. Which of the following is true for this drug:

It is used to prevent thrombosis in unstable angina

It is only approved following percutaneous coronary intervention in which a stent was placed

It should be given away from meals to prevent low absorption rates

A main side effect is constipation

2-One of the these diuretics can be given to patients with renal failure and is not likely to accumulate in their bodies?

Hydrochlorothiazide

Indapamide

Chlorthalidone

Mannitol

Solutions

Expert Solution

1. The answer is ------

It is used to prevent thrombosis in unstable angina.

Clopidogrel is an antiplatelet aggregator. It reduces the formation of blood clots which are responsible for thrombosis causing stroke, angina, myocardial infraction by binding to platelet receptors P2Y¹² class of Adenosine diphosphate which is irreversible. When there is unstable angina, the blood flow in the arteries is interrupted which may cause thrombosis complicating it further . Therefore, clopidogrel is given.

While other options include -

It is given orally or injectable forms and side effects include dizziness, diarrhoea, nose bleeds.

2. The answer is ---- Indapamide

Indapamide is used in treatment of high blood pressure and as diuretic in renal failure. It is considered safe to be administered in chronic renal insufficiency which reduces the body's extracellular fluid volume and also reduces peripheral vascular resistance.

While other options include -

Chlorthiazides belong to thiazide group of diuretics which has no much action on renal failure.
Mannitol is contraindicated in renal failure as it is osmotic diuretic used in treatment of brain edema.
Chlorthalidone increases the creatinine levels and is not a choice in renal failure.

Thank you.

Nightingale answered 1 year ago

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