How many rounds of β-oxidation are necessary for the complete oxidation of stearic acid (18:0)? How...

How many rounds of β-oxidation are necessary for the complete oxidation of stearic acid (18:0)? How many molecules of NADH, FADH2,and Acetyl CoA are generated? Assuming that the Acetyl CoA is further metabolized by the citric acid cycle, how many more NADH, FADH2and GTP are generated? Starting with free stearate in the cytosol, how many ATP are generated by the complete oxidation of stearate to CO2followed by oxidative phosphorylation of the produced NADH and FADH2?

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Expert Solution

Ans.

How many rounds of β-oxidation are necessary for the complete oxidation of stearic acid (18:0)?

8 rounds of β-oxidation are necessary for the complete oxidation of stearic acid (18:0).

How many molecules of NADH, FADH2, and Acetyl CoA are generated?

35 molecules of NADH, 17 molecules of FADH2, and 9 molecules of Acetyl CoA are generated.

NADH =(8+27)=35 [ 8 for 8 rounds and 27 from 9 Krebs cycle of 9 acetyl CoA (9×3 =27)
FADH2 =(8+9)=17 [ 8 for 8 rounds and 9 from 9 Krebs cycle of 9 acetyl CoA (9×1=9]
Acetyl CoA =9

Assuming that the Acetyl CoA is further metabolized by the citric acid cycle, how many more NADH, FADH2and GTP are generated?

NADH =(9×3)=27
FADH2 =(9×1)=9
GTP =(9×1)=9

Starting with free stearate in the cytosol, how many ATP are generated by the complete oxidation of stearate to CO2 followed by oxidative phosphorylation of the produced NADH and FADH2?

ATP = (ATP from NADH)+(ATP from FADH2)+(ATP which is similar to GTP)
= (24+81)+(16+18)+(9)
= 148

gladiator answered 1 year ago

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