Question

1A) Explain the relationship between addiction and the nucleus accumbens.

Describe how these drugs affect neurons: reserpine, textrodotoxin, amphetamine, caffeine, cocaine, curare, nicotine and alcohol.

Answer 1

The core accumbens plays a crucial part in addictions. Sedate or substance manhandle causes an over the top sum of dopamine to be discharged, making us feel delight. Hence, we are able to make an affiliation between the substance and feeling great so we will tend to proceed to consume. One of the capacities of the accumbens is the motivation for activity, in the arranging and restraint of behaviors, due to its associations with the prefrontal cortex.

Caffeine essentially diminishes dihydroxyphenylacetic acid levels in the hypothalamus,striatum and frontal cortex, but increments DOPAC amount in the core accumbens.

The amphetamines increment synaptic norepinephrine and dopamine by constraining the transporters to function in invert.

Cocaine increments synaptic norepinephrine and dopamine by blocking the transporter proteins that evacuates these catecholamine transmitters from the synapse.

Reserpine restrains the take-up of norepinephrine into capacity vesicles coming about in consumption of catecholamines and serotonin from central and fringe axon terminals.

Nicotine actuates cholinergic neurons that ordinarily utilize acetylcholine to mediate with other neurons in numerous distinctive locales all through your brain simultaneously. Due to the unregulated incitement and disturbance, the body increments its discharge of acetylcholine, driving to increased action in cholinergic pathways all through your brain. Action in the cholinergic pathways calls your body and brain into activity, and you feel re-energized.