Question

In: Chemistry

In 1925, E. Gorter and F. Grendel, studied erythrocytes from a dog and obtained data similar...

In 1925, E. Gorter and F. Grendel, studied erythrocytes from a dog and obtained data similar to the following: volume of packed cells (38 mL); number of cells (7.96 x 106 per mm3); Total surface area of lipid monolayer from cells (63 m2); Total surface area of one cell (98 μm2). Calculate the total surface area (in terms of μm2 to the nearest ones) of lipid monolayer per cell. Think about whether the figure you calculated supports the claim that cell membranes are composed of a bilayer.

Solutions

Expert Solution

Ans. Given,

            Total packed volume of cells = 38 mL

            Cell density = 7.96 x 106 cells/ mm3                                  ; [1 mm3 = 0.001 mL]

= 7.96 x 109 cells/ mL

            Total surface area of lipid monolayer = 63 m2                ; [1 m = 106 um]

                                    = 63 x (106 um)2

                                    = 6.3 x 1013 um2

Now,

Total number of cells in 38 mL sample = Cell density x packed volume

                                    = (7.96 x 109 cells/ mL) x 38 mL

                                    = 3.0248 x 1011 cells

Now,

Surface area of lipid monolayer per cell = Total area of lipid monolayer / Number of cells

                                                            = (6.3 x 1013 um2) / (3.0248 x 1011 cells)

                                                            = 208.28 um2 / cell

                                                            = 208 um2 / cell

# Each cell is made up of lipid bilayer. A bilayer consists of two sheets of the monolayer.

So,

Total surface area of lipid bilayer per cell = (Surface area of lipid monolayer per cell) / 2

                                                            = (208 um2 / cell) / 2

                                                            = 104 um2 / cell

Therefore, total surface area of a cell (enclosed by lipid bilayer) = 104 um2 / cell

# Comparison: The calculated value of lipid bilayer surface area per cell of 104 um2/ cell is in close agreement with the given value of 98 um2/ cell.


Related Solutions

In 1925, E. Gorter and F. Grendel, studied erythrocytes from a dog and obtained data similar...
In 1925, E. Gorter and F. Grendel, studied erythrocytes from a dog and obtained data similar to the following: volume of packed cells (38 mL); number of cells (7.98 x 106 per mm3); Total surface area of lipid monolayer from cells (62 m2); Total surface area of one cell (98 μm2). Calculate the total surface area (in terms of μm2 to the nearest ones) of lipid monolayer per cell. Think about whether the figure you calculated supports the claim that...
Long walks ~ A dog rescue group called K9 guardians studied the walking habits of dog...
Long walks ~ A dog rescue group called K9 guardians studied the walking habits of dog owners. Among a randomly selected 100 Siberian Husky owners, 41 walk their dogs at least a mile every day. Among a randomly selected 97 Golden Retriever owners, 36 walk their dogs at least a mile every day. K9 guardians want to estimate the actual difference between the proportions of Siberian Husky and Golden Retriever owners who walk their dogs at least one mile every...
Let f(x) = e ^−x ^2 . Summarize the pertinent information obtained by applying the graphing...
Let f(x) = e ^−x ^2 . Summarize the pertinent information obtained by applying the graphing strategy and sketch the graph of y = f(x)
Show that, for any events E and F, P(E ∪ F) = P(E) + P(F) −...
Show that, for any events E and F, P(E ∪ F) = P(E) + P(F) − P(E ∩ F). Only use the probability axioms and indicate which axiom you use where
E ::= E + T | T T ::= T * F | F F ::=...
E ::= E + T | T T ::= T * F | F F ::= num | (E) Num ::= 0 | 1 | 2 | 3 | 4 | 5 | . . . . . . . Question: 1 a. Show the Left-most derivation for the expression: 5 * 7 + 6 * (1 + 2). b. Show the Right-most derivation for the expression: 5 * 7 + 6 * (1 + 2).
1. A dog rescue group called K9 guardians studied the walking habits of dog owners. Among...
1. A dog rescue group called K9 guardians studied the walking habits of dog owners. Among a randomly selected 100 Siberian Husky owners, 41 walk their dogs at least a mile every day. Among a randomly selected 103 Golden Retriever owners, 38 walk their dogs at least a mile every day. K9 guardians want to estimate the actual difference between the proportions of Siberian Husky and Golden Retriever owners who walk their dogs at least one mile every day. Notation:...
Chapter 6- Question # 2 e, f Researchers have collected data from a random sample of...
Chapter 6- Question # 2 e, f Researchers have collected data from a random sample of six students on the number of hours spent studying for an exam and the grade received on the exam as given in Table 6.5. Table 6.5 Observation Grade Number of Hours Studying 1 85 8 2 73 10 3 95 13 4 77 5 5 68 2 6 95 12 e) Find and interpret a 99% confidence interval for the predicted grade for an...
Using historical data of similar products sold in the previous season and looking at their A/F...
Using historical data of similar products sold in the previous season and looking at their A/F ratio (actual demand/forecasted demand) is one way of establishing the variation in the forecast accuracy. This method allows us to calculate a mean and standard deviation for a product's forecast based on a forecast given by marketing. For example, marketing thinks we will sell 3,200 Hammer 3/2s. Using the historical data, we adjust this forecast to: Expected actual demand for Hammer 3/2 (μ) =...
Please use R to solve part e and f The data file data2.txt gives a data...
Please use R to solve part e and f The data file data2.txt gives a data set with two variables x and y. The first column in the data set is just row numbers not useful for this question. (e) Use the Shapiro-Wilks test to test for Normality of the data. State your null and alternative hypotheses, p-value and conclusion. Use α = 0.05 (f) Apply the transformation y 0 = log(y) and run the regression on y 0 on...
Trypsin is a proteolytic enzyme that displays a similar mechanism to the studied for chymotrypsin (serine...
Trypsin is a proteolytic enzyme that displays a similar mechanism to the studied for chymotrypsin (serine protease). Tosyl-L-lysine chloromethyl ketone is a specific inhibitor of trypsin. Why is this compound specific for trypsin?
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT