Why is lactic acid accumulation in the blood during exercise an indicator of fatigue?

Expert Solution

Sydney Mullin answered 1 year ago

Explain how acid accumulation in a muscle fiber could contribute to fatigue.

You need to perform a titration of lactic acid. What indicator would you use to best...

You need to perform a titration of lactic acid. What indicator would you use to best align the end point with the equivalence point? You will need to support your decision with calculations, including the pH at the equivalence point.

The analytical concentration of lactic acid in blood is generally less than 1.20 x 10-4 M,...

The analytical concentration of lactic acid in blood is generally less than 1.20 x 10-4 M, corresponding to the sum of [lactate] and [lactic acid]. During strenuous exercise, however, oxygen in the muscle tissue is depleted, and overproduction of lactic acid occurs. This leads to a condition known as lactic acidosis, which is characterized by elevated blood lactic acid levels (approximately 5.00 x 10-3 M). The pKa of lactic acid is 3.9. 1. What is the actual lactic acid concentration...

Why is the lactic acid test done when sepsis is suspected? Explain why the body produces...

Why is the lactic acid test done when sepsis is suspected? Explain why the body produces excess lactic acid during sepsis (Be sure to cover all possibilities). How does this relate to fermentation and final electron acceptors during metabolism?

What is the origin of the lactate or lactic acid?

Q: Blood Lactate Levels during Vigorous Exercise. The concentrations of lactate in blood plasma before, during,...

Q: Blood Lactate Levels during Vigorous Exercise. The concentrations of lactate in blood plasma before, during, and after a 400 m sprint are shown in the flowing graph. a. What causes the rapid rise in lactate concentration? b. What causes the decline in lactate concentration after completion of the sprint? Why does the decline occur more slowly than the increase? c. Why is the concentration of lactate not zero during the resting state?

Titration Problem: Lactic acid, HC3H5O3 (see right for structure), builds up in muscles after vigorous exercise....

Titration Problem: Lactic acid, HC3H5O3 (see right for structure), builds up in muscles after vigorous exercise. It is a weak acid with a pKa = 3.86. Consider the following titration: 25.0 mL 0.500 M lactic acid is titrated with 1.00 M NaOH. Answer the following questions: 1. What is the pH of the lactic acid solution before any NaOH is added? 2. What is the pH after 5.00 mL of 1.00 M NaOH is added? 3. What is the pH...

During exercise, how/why does a larger percentage of blood (cardiac output) go to skeletal muscles?

A solution containing a mixture of lactic acid and lactate was found to have a pH of 3.56. Calculate the ratio of the lactate concentration to the lactic acid concentration in this solution.

During exercise when the body lacks an adequate supply of oxygen to support energy production, the pyruvate that is produced from the breakdown of glucose is converted into lactate. High lactate levels can lead to acidity in the muscle cells as some of the lactate hydrolyzes to lactic acid. The dissociation of lactic acid to lactate is shown in the reaction below. Lactic acid has a pKa of 3.86. A solution containing a mixture of lactic acid and lactate was found to...

How do lactic acid homofermemtative pathway and heterofermentative pathway differ in their glycolytic pathways? Why do...

How do lactic acid homofermemtative pathway and heterofermentative pathway differ in their glycolytic pathways? Why do they differ in these pathways and what is the advantage of the two alternate glycolytic pathways vs. the classical EMP glycolytic pathway?

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