In: Anatomy and Physiology
An individual is admitted to a hospital rehab center for opioid dependence. They began therapy using Suboxone (partial agonist) at 50 mg/day. Each week, their dosage was reduced by 10 mg until they weaned off the medication. They were then released and sent home. Explain what happened physiologically during their treatment
Answer )
Suboxone comes in Sublingual form and is Combination of Buprenorphine and Naloxone .
Buprenorphine is partial opioids agonist and Naloxone is opioids antagonist .
Opiods acts through its receptors and there are three receptors mu,Kappa and Delta .
Mu receptor | kappa | Delta |
Sedation | Dysphoria (Psychomimmetic effects ) | Spinal analgesia |
Analgesia | Constipation | Modulation of hormone |
Constipation | Analgesia | Neurotransmitter release |
Respiratory depression | ||
Truncal Rigidity | ||
Euphoria | ||
Meiosis |
Opiods are highly addictive substances and suden discontinuation lead to withdrawal syndrome characterised by Rhinnorhea ,Lacrimation,Yawning ,Mydriasis ,Vomiting ,Diarrhea and Anxiety .Most of these symptoms are opposite to normal actions of Opioids .
If addiction is of long duration sudden withdrawal may be dangerous ( due to above withdrawal symptoms ) .In such Buprenorphine act as partial agonist and prevent from withdrawal symptoms through its physiological actions on mu receptors by stimulating it and is much less addictive .Naloxone help to prevent relapse after deaddiction .Naloxone prevents Euphoric action by blocking Mu receptors .