Question

What happens if you have an imbalance between osteoblasts and osteoclasts? Specifically, what happens when you have too many osteoblasts versus when you have too many osteoclasts?

Answer 1

*Bones are living tissue that is constantly growing, replacing,rebuilding and repairing.

*Bone is made up of Living cells Osteoblast and osteoclast .It is made up of Mineralised organic matrix and inorganic Hydroxyappatite crystals and salt of calcium and phoshate.

*Bone deposition ( formation ) is the result of osteoblasts while bone resorption is the function of osteoclasts.

*Osteoblast ---->Makes the osteoid from proteins .Allow for mineralisation to form Osteon / Bone .It is made up of mononuclear cell .Osteoblast form immature cartilage like woven bone by forming Soft Callus which get converted into Hard callus and form Lamellar bone.

*Osteoclast ----->Used for Resorption of bone .They are multinucleated bone cells made up by fusion of Monocyte .

*Balance between osteoblast and osteoclast is very important for remodelling of bone .

*If imbalance occur then due to overactivity of Osteoclast excess resorption of bone take place and result in Osteoporosis ( weak bone ).

*If the osteoblasts become overactive and too much bone tissue is produced, which leads to enlargement and overgrowth of bone which is abnormal .The condition is known as Paget's Disease .The abnormal growth means that the new bone tissue is weak and unstable. The new bone also contains more blood vessels than normal bone.