In: Statistics and Probability
A geneticist is studying two genes. Each gene can be either dominant or recessive. A sample of 100 individuals is categorized as follows. Write your answer as a fraction or a decimal, rounded to four decimal places.
Gene 2.
Dominant(gene 2) | Recessive(gene 2) | |
Dominant gene1 | 53 | 27 |
recessive gene 1 | 17 | 3 |
Gene 1
(a) What is the probability that in a randomly sampled individual, gene 1 is recessive? (b) What is the probability that in a randomly sampled individual, gene 2 is recessive? (c) Given that gene 1 is recessive, what is the probability that gene 2 is recessive? (d) Two genes are said to be in linkage equilibrium if the event that gene 1 is recessive is independent of the event that gene 2 is recessive. Are these genes in linkage equilibrium?
Dominant (G2) | Recessive (G2) | total | |
Dominant (G1) | 53 | 27 | 80 |
Recessive (G1) | 17 | 3 | 20 |
total | 70 | 30 | 100 |
a) Probability that Gene 1 is recessive = 20 /100 =0.2
Note : This is marginal probability , thus we find it by dividing marginal total ( row total for gene 1 ) by grand total
b) Probability that Gene 2 is recessive=30 /100= 0.3
Note : This is marginal probability , thus we find it by dividing marginal total ( column total for gene 2 ) by grand total
c) P ( Gene 2 recessive I Gene 1 recessive )
= P( Both Gene 1 and Gene 2 recessive ) / P( Gene 1 recessive)
= (3/100) / (20 /100)
= 0.15
Note : This is conditional probability , we find it by dividing joint probability / marginal probability
d) Event of Gene 1 recessive and Gene 2 recessive are said to independent if
P ( Gene 2 recessive I Gene 1 recessive ) = P( gene 2 recessive)
(that is conditional probability of Gene 2 recessive =un conditional probability Gene 2 recessive)
But , P ( Gene 2 recessive I Gene 1 recessive ) = 0.15
and P( gene 2 recessive) = 0.3
Thus the events Gene 1 recessive and Gene 2 recessive are not independent
The two genes are not in linkage equlibrium .