Question

Please answer the following multiple choice questions

1. What cell type makes sure that antibodies produced against microorganisms will target structures on the surface of the microorganism?

a. Helper T cells

b. B cells

c. Macrophages

d. Killer T cells

2. If a macrophage phagocytosed a virus, viral peptides would be presented on

a. MHC-I

b. MHC-II

c. CD* T cell receptors

d. CD4 T cell receptors

3. For a mouse to make antibodies against a small molecule, such as benzene

a. inject a protein into the mouse

b. inject a benzene-protein complex into the mouse

c. inject benzene into the mouse

d. none of the above

Answer 1

1.Answer- B cells

Antibodies present on the surface of B cells are made up of glycosylated protein molecule (immunoglobulin) act as the antigen receptor which helps in binding and neutralizing the target microorganisms.Helper T cells functions in activating the B cells,macrophages and cytotoxic cells (killer T cells ) in order to kill the pathogens.

2.Answer- MHCI

If macrophage engulf the virus through phagocytosis which process the viral antigen on the MHC I molecules via the internalization of viral peptide and secretion of viral peptide with MHC I at cell surface. CD4 and CD8 cell receptors are present on the surface of the immune cells.MHCII is present on the antigen presenting cells on macrophages,dendritic cells and B cells.

3.b. inject a benzene-protein complex into the mouse

The small molecules (haptens) are less immunogenic,therefore it needs to be conjugated with carrier protein to generate a strong immunogenic response in mouse. The injecting benzene alone in the mouse would fail to generate an immune response and antibodies.