pharmacology question Why do you expect an ACE inhibitor to increase renin release and the rate...

pharmacology question

Why do you expect an ACE inhibitor to increase renin release and the rate of formation of angiotensin I?

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Expert Solution

Answer

Normally, when sodium chloride levels decrease, macula densa cells release renin.
Renin activates angiotensin-1 and ACE is an enzyme that helps in production of angiotensin-II.
Angitensin -II stimulates the release of aldosterone from adrenal cortex.
Aldosterone acts on distal convoluted tubule to increase reabsorption of sodium chloride as well as water.
When enough NaCl and water are reabsorbed, a negative feedback inhibits the release of renin from kidney.
Hence, it also stops angiontensin-I production.

- ACE inhibitor is a drug that inhibits the action of angotensin-converting-enzyme to convert angiotensin-I into angiotensin-II.
- Unavailability of angiotensin-II cannot stimulates the release of aldosterone.
- As a result, there is no initiation of NaCl and eater retension.

The sodium chloride levels continue to decline.

Declining NaCl levels further stimulate the release of renin.

More renin acts on angiotensinogen to increase production of angiotensin-I.

Hence, it is expected for an ACE inhibitor to increase renin release and the rate of formation of angiotensin I.

Sydney Mullin answered 8 months ago

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