In: Anatomy and Physiology
pharmacology question
Why do you expect an ACE inhibitor to increase renin release and the rate of formation of angiotensin I?
Answer
- ACE inhibitor is a drug that inhibits
the action of angotensin-converting-enzyme to convert
angiotensin-I into angiotensin-II.
- Unavailability of angiotensin-II
cannot stimulates the release of
aldosterone.
- As a result, there is no initiation of NaCl and eater
retension.
The sodium chloride levels continue to decline.
Declining NaCl levels further stimulate the release of renin.
More renin acts on angiotensinogen to increase production of angiotensin-I.
Hence, it is expected for an ACE inhibitor to increase renin
release and the rate of formation of angiotensin I.