Question

Explain how the release of FSH is regulated by negative feedback. Be sure to include all the hormones that are involved and how they affect the release of FSH.

Answer 1

FSH or follicle stimulating hormone is secreted from the anterior pituitary gland by the action of the GnRH (Gonadotrophin releasing hormone ) produced from the arcuate nucleus of the Hypothalamus.

FSH hormone is released in both male and female.

In males, when Hypothamo-pituitary gonada axis is activated , the Hypothalamus will release GnRH , it will eventually act on the receptor present on teh anterior pituitary gland . it will further secret LH and FSH hormones.

FSH hormone in male will act on the sertoli cell of the testis and LH hormone act on the Leydigs cell of the testis and produce Testosterone.

When the level of the FSH and the Testosterone become high it will inhibit the secretion of the GnRH from teh Hypothalamus thsu the level of the  FSH and LH are controlled by the negative feedback mechanism

Llike that in females,

During the period of puberty the Hhypothalamus releases GnRH which will activate the anterior pituitary gland to secrete FSH and LH.

FSH act on the follicle for teh developement of the primordial follicle to matured follicle.

When the mature folicle releases the Secondary Oocyte by the process called ovulation the remainig part of the follicle will be converted to the Corpus luteum.

Corpus luteum will secrete progesterone for the development of the endometrium for implantation.

The high level of the estrogen and progesterone will inhibit the prodution of teh FSH from the anterior pituitary through negative feedback mechanism.