Question

Explain (in detail) the entire development of the limbs?

Answer 1

Answer :- The entire development of the limbs included the following given steps
•Limb buds potrude from the sides of the vertebrate embryo.
•Limb buds grow and are patterned along the three axes resulting in the establishment of cartilage templates that prefigure the bones.
•The mesenchymbal cells aggregate to form pre- chondrocyte condensations.
•the chondrocyte cells stop dividing and differentiate into hypertrophic chrondrocytes, which begin to secrete extracellular matrix proteins .
•Once the cartilage elements have formed the hypertrophic chrondrocytes undergo apoptosis.
•Their death allow blood vessels to enter, bringing in osteoblasts.
•The osteoblasts invade the mineralized matrix laid down by the hyperchondocytes and deposit bone matrix.
•While the osteoblasts replace the hypertrophic chrondrocytes at the centre of the cartilage template the chondrocyte at the end continue to proliferate and form the growth plates at the end of the bones.Thanks dear student