Describe 2 major challenges in skeletal muscle regeneration for muscular fibrosis. (3 mins)

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Expert Solution

Excessive accumulation of Extra Cellular Matrix components , especially collagen, is defined as fibrosis, either due to excessive Extra Cellular Matrix production, alteration in Extra Cellular Matrix -degrading activities or a combination of both. Skeletal muscle fibrosis impairs muscle function, negatively affects muscle regeneration after injury and increases muscle susceptibility to re-injury and is therefore considered to be a major cause of muscle weakness.

Skeletal muscles have some ability to regenerate and form new muscle tissue.

muscle fibrosis can be reversed pharmacological and myostatin inhibitors, a novel therapy to stimulate muscle regeneration.

Challenges in skeletal muscle regeneration for muscular fibrosis.

1.Repetition of injury weakens the healing capacity of skeletal muscles and injury grows to fibrosis.Fibrosis weaks the muscle and put pressure on nerves and cause pain.Traumatic muscle injury.

2.It is caused when interaction between myogenic progenitors and skeletal muscle gets weak due to which regeneration of skeletal muscle gets weaken and then injury progess into muscle fibrosis because of weakening of healing action of skeletal muscles.

Sydney Mullin answered 9 months ago

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