26. With respect to alternative endocytosis pathways which statement is CORRECT? A.Macropinocytosis only occurs when triggered...

26. With respect to alternative endocytosis pathways which statement is CORRECT?

A.Macropinocytosis only occurs when triggered by bacteria.

B.All cells can phagocytosebacteria.

C.All endocytosis pathways delivery their content to early endosomes.

D.Both macropinocytosis and phagocytosis contribute to processes involved in the host immune response.

E.Some endocytosis pathways occur from the Trans-Golgi Network.

Expert Solution

A. Macropinocytosis only occurs when triggered by bacteria. This statement is incorrect as micropinocytosis is non specific and can be triggered by extracellular molecules, nutrients and antigen.

B. All cells can phagocytose the bacteria. This statement is incorrect as only neutrophils, macrophages, dendritic cells and B lymphocytes can phagocytose the bacteria.

C. All endocytosis pathway deliver their content to the early endosomes. This statement is also incorrect as all the content is delivered to lysosomes or late endosomes for degradation. Early endosomes is responsible for dissociating the ligand and receptor due to low pH and also perform sorting for delivery.

D. Both macropinocytosis and phagocytosis contribute to the processes involved in the host immune reponse. This statement is correct as micropinocytosis takes up the antigen and present them on MHC I and MHC II for activation of the T cell response. On the other hand various immune cells such as macrophages, neutrophils, dendritic cells and B cells phagocytose the antigen and then present on the MHC for further immune response.

E. Some endocytosis pathway occur from Trans Golgi network. This statement is incorrect as TGN signals the endocytosis pathway and perform sorting but the process do not occur in TGN.

gladiator answered 1 year ago

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