Question

Transgenic mice are manipulated to express already recombined genes for a specific T cell receptor (alpha and beta chains) in their cells. These mice will only possess T cells with these introduced T cell receptors

-if their own bone marrow is rendered inactive by irradiation

-if their normal T cell receptor genes for alpha chains and beta chains are defective

-because of allelic exclusion in beta chain gene expression and positive selection stopping alpha gene segment recombination

-if the introduced TCR binds moderately to one of the MHC molecules of the new host

4a. If the peptide recognized by the above introduced transgenic T cell receptor in (3) is injected into the thymus of mice and the MHC restriction of this T cell receptor does match one of the MHC alleles of the mice, the result will be

a-massive T cell activation and proliferation in the periphery

b-massive T cell activation and proliferation in the thymus

c-massive T cell apoptosis

d-no response will be observed

4B). Short answer. Explain why for 4A:

Answer 1

OPTION

b) massive T cell activation and proliferation in the thymus.

4B) ANSWER

• Basically we are know the major histocompatibility complex (MHC) is a restricted antigen, here peptide is nothing but a body observe the protein for developing cell bodies that obseved protein are broken into small parts that is called as peptide, T cell receptors not accepting the MHC molecules because MHC complex have a own self antigen so the T cell receptors does not react but some particular MHC molecues react to T cell receptor for action, T cell accept to develope the thymocytes in thymus because that thymus having a binding capable type, sometime a recepters will get infected means a MHC molecules does not combine to T cell.

4A) ANSWER

• The T cell get there own function properly a leaves thymus and then T receptors bind to the MHC, here i tell about use massive T cell activation and proliferation in the thymus is a does not match to MHC alleles.