Describe and compare cross-bridge activation in cardiac and smooth muscle cells.

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Properties	Cardiac Muscle	Smooth Muscle
Arrangement	Have striated appearance,with arrangement of thick and thin filaments that make up contractile apparatus	Have actin and myosin contractile proteins and thick and thin filaments.
Regulatory protein	Troponin and tropomyosin	Cross bridge formation regulated by calmodulin
Presence of bands	Have I band, A band and Z disk.	Presence of dence bodies
Muscle contraction features	Contraction is regulated by Ca ionsand by thin filament based troponin tropomyosin complex.	During muscle fiber contraction, midsection will bulge in a corkscrew motion.
Maintenance of muscle contraction	Ca bind to low affinity site on troponin C , which alters interaction of proteins of thin filament strand, leads to tropomyosin movement from its blocking position and binding of cross bridges to actin.	Formation of latch-bridges between myosin heads and actin , keep the link together for a prolonged period, without use of ATP.

Sydney Mullin answered 9 months ago

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