Approximately how many net molecules of ATP are used or generated by gluconeogenesis as compared to...

Approximately how many net molecules of ATP are used or generated by gluconeogenesis as compared to net ATP used or generated by glycolysis?

Expert Solution

During glycolysis, one ATP is utilized during the conversion of Glucose to Glucose 6-phosphate and one ATP is required for the synthesis of Fructose 1,6-bisphosphate from Fructose 6-phosphate.

Two ATP are generated when two molecules of 1,3-Bisphosphoglycerate are converted to 3-Phosphoglycerate and two ATP are generated when Phosphoenolpyruvate is converted into Pyruvate.

Two NADH are synthesized when Glyceraldehyde 3-phosphate is converted to 1,3-Bisphosphoglycerate.

So overall yield of ATP is 4-2 = 2.

During gluconeogenesis, pyruvate is converted into phosphoenolpyruvate through oxaloacetate. This conversion required two ATP per pyruvate molecules.

One ATP is required when 3-Phosphoglycerate is converted to 1,3-Bisphosphoglycerate.

So, a total of 6 ATP are required to make glucose from pyruvate via gluconeogenesis.

So the net molecules of ATP used by gluconeogenesis are 6 and 2 ATP are generated during glycolysis,

gladiator answered 2 years ago

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