Question

What are 3 molecular pathways in astrocytes that can result in epileptogenesis?

Answer 1

Status epilepticus is a life threatening condition that often precedes the development of epilepsy.

Status epilepticus can result in temporal lobe epilepsy.status epilepsy is a medical emergency with poor prognosis.it is defined as continued seizure activity lasting greater than 5 minutes or twonor more sequencial seizure without recovery between seizure.

Properties if reactive gliosis following SE.

Reactive astrocytes become hypertrophic,increase expression of intermediate filament protiens and develop longer and thicker process.

Potassium buffering is not altered shortely after SE.

astrocytes play a critical role in maintaining neuronal homeostasis by buffering extracelluar potassium through highly permeable, inwardly rectifying potassium channel.

Neurons extrude potassium with each action potential repolarization and period of high activity potassium concentration in the extracelluar space can be rapidly elevated