Question

Compare and contrast the functions and metabolism of VLDL and chylomicrons

Answer 1

Chylomicrons are ultra low-density lipoproteins (ULDL),  that consist of triglycerides ,cholesterol, phospholipids and proteins .( Chylomicrons carry very little cholesterol & a lot of triglycerides)

Chylomicrons are made in Intestinal Cells.

Chylomicrons transport Triglycerides(Fat) from intestine -------- Liver,Skeletal muscle and Adipose tissue.

The triglycerides carried in chylomicrons-----metabolized in muscle and adipose tissue by lipoprotein lipase which release free fatty acids,(Fatty acids)which are subsequently metabolized by muscle and adipose tissue.Also,chylomicron remnants are formed,which are taken up by the liver.

VLDL(Very-low-density lipoprotein) is one of the 5 major groups of lipoproteins

VLDL are lipoprotein made by the liver.

it contains cholesterol, triglycerides& proteins.(Cholestrol content is High)

VLDL Helps fats and cholesterol to move within the water-based solution of the bloodstream.

VLDL deliver triglycerides to body cells, which is needed for cellular processes.

VLDL is called Bad cholestrol,as it causes cholestrol deposits in Blood & high levels of cholesterol can clog your arteries & cause heart attack.

VLDL ----------- intermediate density lipoprotein (IDL)(By Lipoprotein Lipase) ------ low density lipoprotein (LDL) (by action of hepatic lipase (HL) and LipoproteinLipase)

IDL and LDL are then removed by the liver by LDL receptor & LDL receptor-related protein. Cholesteryl ester (CE) can be transferred from LDL to  VLDL by cholesteryl ester transfer protein (CETP) in exchange for triglycerides (TG)