Due to the wobble hypothesis, which position in the codon, if changed to a different nucleotide,...

Due to the wobble hypothesis, which position in the codon, if changed to a different nucleotide, would be least likely to cause a change in the amino acid encoded? The codon is in the mRNA.

a) first or 5' nucleotide of the codon

b) second (middle) nucleotide of the codon.

c) any nucleotide of the codon.

d) Either the first (5') or second (middle) nucleotide of the codon.

e) third or 3' nucleotide of the codon .

Expert Solution

The wobble position of a codon refers to the 3rd nucleotide in a codon. This nucleotide has two major characteristics:

Binding of a codon in an mRNA the cognate tRNA is much "looser" in the third position of the codon. This permits several types of non-Watson–Crick base pairing to occur at the third codon position.
The genetic code is redundant whereby several different codons code for the same amino acid. Often, this redundancy is specified in the third codon position such that several codons with the same first two nucleotides, but different third position nucleotides, code for the same amino acids

So, option e (third or 3' nucleotide of the codon ) is the cirrect answer.

gladiator answered 2 years ago

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