If Substance X is administered at the same time as penicillin, the length of time the...

If Substance X is administered at the same time as penicillin, the length of time the penicillin can be found in the blood of the patient is prolonged. Which of the following is the most likely reason why?

		Substance X increases the secretion of penicillin into the tubular fluid
		Substance X and penicillin compete for the same renal transporter responsible for reabsorption.
		Substance X and penicillin complete for the same renal transporter responsible for secretion
		Substance X prevents the reabsorption of penicillin from the tubular fluid
		Substance X increases the filtration of penicillin into Bowman's capsule

Expert Solution

The correct answer is C

Explanation:

Firstly let's clear doubts about tubular reabsorption and secretion..

In excretory stage of pharmacokinetics we can effectively increase or decrease the length of time a drug is present in the blood by two methods

a) either by controlling the tubular reabsorption

b) or by controlling drug's tubular secretion

In the above question we control penicillin's tubular secretion.

To make penicillin long acting, drugs like probenecid (here, substance X) is given; since probenecid has greater affinity for the transporter than penicillin. And thus penicillin is retained in the blood and not secreted back into the filtrate.

Sydney Mullin answered 1 year ago

A. College Students’ Recent Life Experiences. Researchers administered to 216 undergraduate students (in the same time...

A. College Students’ Recent Life Experiences. Researchers administered to 216 undergraduate students (in the same time period) the Inventory of College Students’ Experiences and a measure of daily hassles. The total coefficient alpha was .92 for the Inventory and .96 for the measure of daily hassles. The Inventory correlated with daily hassles at .76 (p <. 001). B. Test scores for the Eysenck Personality Inventory and Cattell’s 16 Personality Factor Questionnaire (16PF) were obtained for male army applicants for flyer...

Let 'x' be a random variable that represents the length of time it takes a student...

Let 'x' be a random variable that represents the length of time it takes a student to write a term paper for Dr. Adam's Sociology class. After interviewing many students, it was found that 'x' has an approximately normal distribution with a mean of µ = 7.3 hours and standard deviation of ơ = 0.8 hours. For parts a, b, c, Convert each of the following x intervals to standardized z intervals. a.) x < 8.1 z < b.) x...

Activity 9: Linear Regression and Correlation Analysis Scenario: A graduate student has administered a pro-inflammatory substance,...

Activity 9: Linear Regression and Correlation Analysis Scenario: A graduate student has administered a pro-inflammatory substance, lipopolysaccharide (LPS), to humans in the form of a pill (several doses – 0mg or placebo, 5mg, 10mg, and 15mg). She then determines the blood concentration of a particular protein that is thought to be upregulated due to LPS (mg) called Inflammotin (pg/ml) using ELISA. Find the linear model and the correlation coefficient of the experimental data (in JMP and Excel) using the data...

Roll two dice at the same time, and define a random variable X as the sum...

Roll two dice at the same time, and define a random variable X as the sum of the two faces observed. Determine the CDF and PMF of X. Sketch the CDF.

Construct a cooling curve (looks the same as a heating curve) for a substance with a...

Construct a cooling curve (looks the same as a heating curve) for a substance with a molar mass of 200 that has a gas phase specific heat capacity of 2.9 J/g-K, a boiling point of 525 K, a liquid phase specific heat capacity of 3.24 J/g-K, a freezing point of 352 K, a solid phase specific heat capacity of 3.3 J/g-K and molar enthalpies of fusion and condensation of -14.3 kJ/mol and -46.4 kJ/mol. Also what is the difference between...

13.18 Two piano strings with the same mass and the same length are to be tuned...

13.18 Two piano strings with the same mass and the same length are to be tuned to 440 Hz (A on the equal temperament scale). One string, with a tension of 300 N is already tuned to 440 Hz. The second string frequency is 435 Hz. a) Should the tension of string 2 be increased or decreased to tune the frequency to 440 Hz? b) How much must the tension of string 2 be changed to change the frequency from...

Two substances, A and B, have the same mass. Substance A is at a higher temperature...

Two substances, A and B, have the same mass. Substance A is at a higher temperature than B, and heat transfers between them until equilibrium is reached. The decrease in the temperature of A is less than the increase in temperature of B. Which substance has the larger specific heat?

If two blood vessels carry blood with the same viscosity. They have the same length but...

If two blood vessels carry blood with the same viscosity. They have the same length but different cross section areas where A1 > A2. IF the Hagan-Poiseuille Law applies and both vessels require the same flow rate. Which vessel has the larger pressure drop? Vessel 1 or Vessel 2?

In pegasus genetics, horn length, feather color, and tail length genes are located on the same...

In pegasus genetics, horn length, feather color, and tail length genes are located on the same chromosome. Each gene has two alleles: wild type, which is dominant, or mutant, which is recessive. H is dominant and results in long horns; h is recessive and produces short horns. F is dominant and results in rainbow feathers; f is recessive and produces white feathers. T is dominant and results in a long tail; t is recessive and produces a...

If chicken tarsus length has the same heritability as tree swallow tarsus length, what response to...

If chicken tarsus length has the same heritability as tree swallow tarsus length, what response to selection (R= h2 x S) is expected given the following additional information: Female chicken mean tarsus length is 84 mm. Male chicken mean tarsus length is 91 mm. The farmer breeds from chickens with a mean parental tarsus length of 100 mm

Question