Question

In a twin study on the inability to tolerate excess glucose in the diet (related to the development of diabetes), the MZ concordance was 72% and the DZ concordance was 43%. What percentage of identical twins could tolerate glucose when the other could not? Do these results suggest that diabetes is influenced by genetics? (explain)

Answer 1

Answer) Diabetes mellitus also known as diabetes is a metabolic disorder which occurs when the amount of glucose levels are high in the blood and there isn't enough insulin secretion to maintain blood glucose level,either it happens in type 2 diabetes or there is no production of insulin at all, this happens in type 1 diabetes.

Through twin studies one can know the overall genetic or environmental roles responsible of a particular disease or character. For this there is a comparison between monozygotic twins (identical), twins developed from one zygote and dizygotic twins (fraternal), in which twins develops from separate egg.

Here the monozygotic concordance i.e intolerance level was 72 %. So we say that the tolerance level of monozygotic twins is 28% ( 100-72 ) .

We see that in dizygotic the concordance was 43% which is much less than monozygotic. Which suggest that diabetes is influenced by genetics. Because here monozygotic twins have the same genes and must be having the same abnormal gene for Diabetes

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