Question

Q: New covid-19 vaccine went through clinical trials phase-1 and 2. After analyzing the results, researchers found that this vaccine is deposited more in the fatty tissues. Use your pharmacological knowledge to describe the following phenomenon:

Since covid-19 has a tendency to affect more immunocompromised individuals, do you think this vaccine may cross blood brain barrier in immunocompromised individuals? Please write your answer in the form of “yes” or “no”.  Write two reason to support your answer

What will be the next phase of clinical trial?

Answer 1

The blood-brain barrier (BBB) is a highly selective membrane barrier at the brain microvessel level that facilitates transport between the systemic circulation and the central nervous system. A growing body of evidence supports a major role for the BBB in the etiology and pathogenesis of multiple vascular and neurodegenerative disorders. Recently, an appreciation for the impact of air pollution exposures on neurological function has emerged. The BBB may serve as an intermediary between environmental agents and downstream neurological consequences. This review describes the structure and function of the BBB and its involvement in metabolic, vascular, and neurodegenerative diseases such as diabetes mellitus, stroke, Alzheimer's disease, and multiple sclerosis. The relationship between neuroinflammation and BBB disruption is examined, and a possible role for the BBB in air pollution exposure-associated neurological impairments is discussed. Commonly used clinical and preclinical methods to detect BBB permeability are described as are animal models used to study BBB breakdown. Finally, open questions concerning the impact of environmental stressors on the BBB are explored and current approaches aimed at altering BBB integrity to enhance pharmaceutical uptake into the CNS are discussed.