The pedigree from Parts A and B is shown below. Now it shows the inheritance of a rare recessive autosomal condition that affects individuals II-3, IV-2, IV-5, and V-3 (denoted by the filled symbols and the genotype aa). Individuals I-1, I-2, I-5, and I-6 have no history of this condition in their families.
Genetic Inheritance Patterns: Retinitis pigmentosa (RP) can be
autosomal recessive, autosomal dominant, or x-linked. Apparently
the dominant forms are often less severe. Usher’s Syndrome is an
autosomal recessive inheritance (i.e., you must get a copy of the
defective gene from your Mom and one from your Dad). Autosomal
means it is not carried on one of the chromosomes that determines
sex. One website (http://www.emedicine.com/oph/topic704.htm) says
that Usher’s Syndrome Type II has been mapped to chromosome arm
1qe. Usher’s Type II...
You are expected to prepare a human pedigree detailing the
inheritance of a single
genetic disease or disorder.
The pedigree will be created from the following information:
● There are five generations.
● In generation 1, there are two families.
o family one, the male is affected; this family should be listed on
the
left.
o family 2 the female is affected.
● In generation 2 there are 12 individuals. Information on this
generation:
o family 1 had 7 children,...
5pts) Gaucher’s Disease displays an autosomal recessive pattern
of inheritance and occurs more frequently in individuals of
Ashkenazi Jewish heritage. Gaucher’s Disease is the result of the
loss of an enzyme (encoded by the GBA gene) that catalyzes the
breakdown of glucocerebroside. You have gathered data from a local
population and estimate that approximately 7 in 1000 newborns are
affected by Gaucher’s Disease. (Answer the following questions
using 3 significant digits).
a. Assuming there are only two
alleles, wildtype GBA...
Genetic Disorder: Argininosuccinic Aciduria (use for
bottom section)
Mode of Inheritance: By an autosomal recessive
trait
Scenario 1
Both parents are afflicted with the genetic
disorder.
Parent Genotypes:
Parent Phenotypes:
Punnett Square showing the possible
offspring:
Possible Offspring Genotypes:
Possible Offspring Phenotypes:
Probability Offspring will be afflicted with the
disorder:
Explanation of the results:
Scenario 2
One parent is afflicted with the genetic disorder, and
the second parent does not have the disorder and is not considered
a carrier.
Parent...
In human genetics, what is the difference between autosomal and
sex-link traits?
How does the inheritance pattern for autosomal traits differ
from the inheritance of sex-linked traits ?
The condition shown in this family has multiple possible modes
of inheritance: X-linked recessive, autosomal dominant, and
autosomal recessive. It is always one mode of inheritance for each
family (ie it doesn't change between people within the same
family). Assume full penetrance and onset from birth.
You are trying to determine the mode of inheritance for the
condition in this family. Regardless of the gene it's on, finding a
single pathogenic mutation in who in this family (other than the...
Scalloped (sd) is an X linked recessive and ebony (e) is an
autosomal recessive mutation. What proportion of scalloped, ebony
females (relative to whole population) is expected in the F2
starting with a true breeding scalloped female which is wile type
for ebony mating with a true breeding male mutant only for ebony.
PLEASE break this down step by step and simplify it please. All I
know is the answer is 1/16... no idea how to get it.
If 4% of a population has an autosomal recessive trait, what
portion of the population are likely to be carriers? Assume that
the population is large, and that the recessive trait doesn't
affect fitness of the individual. List your answer as a
percentage.
Human female heterozygotes are unaffected carriers of autosomal
recessive diseases. Explain in one paragraph (4-6 sentences) why
human female heterozygotes can express mild-to-moderate forms of
recessive X-linked disorders.