Question

the body ability to correct an excess or deficit of metabolic acid depend on normal function of what system?

i dont know if it is endocrine system or renal system

please help!

Answer 1

The main system involved in the correction of Metabolic acid imbalance is the Renal System

Acidosis are mainlt two type

1)Respiratory acidosis

2)Metabolic acidosis

Respiratory acidosis is corrected by Metabolic compensation

The frame compensates for the reduced pH from the number one respiratory acidosis by using changing renal excretion of H+. In a chronic respiration acidosis, the body promotes acid excretion via the kidneys (via renal ammoniagenesis in the proximal convoluted tubules), which enhances HCO3– retention (3 x bicarbonate is retained for a single ammonium chloride this is excreted), i.E. The renal compensatory reaction is a secondary metabolic alkalosis. The kidneys can also without delay excrete hydrogen through hydrogen pumps inside the collecting tubules (type A intercalated cells). The kidney’s response starts offevolved within several hours of the onset of a respiratory acidosis, but like any other renal responses, takes three-5 days to be of maximal effectiveness.

2)Metabolic acidosis correction

The kidney can accurate for a number one metabolic acidosis by excreting excess acid as ammonium chloride, generally by better renal ammoniagenesis by the proximal convoluted tubules of the kidney

This regenerates the bicarbonate being fed on in plasma and creates a medullary interstitium this is high in ammonia, in fact 3 bicarbonate molecules are generated for every ammonia produced in the renal tubules from glutamate.

The kidney can also excrete hydrogen actively within the collecting tubules through the V-H-ATPase. In the distal nephron, the hydrogen combines with ammonia (NH3) which passively diffuses across the mobile from the interstitium into the tubular lumen. Once NH4+ is formed, it cannot diffuse back across the membrane and is stuck inside the fluid, so it's far excreted with chloride, this is still within the urine lumen or entered the urine lumen from passively following the hydrogen. So even though ammoniagenesis occurs primarily within the proximal convoluted tubule, it also permits the distal nephron to excrete hydrogen (with chloride). Interestingly, the V-H-ATPase inside the kind A intercalated cells in the cortical and medullary accumulating tubules are typically in vesicles in the cytosol. Decreases in pH (particularly within the cellular) drives the shipping of the pump to the luminal membrane, where it then actively excretes hydrogen with chloride following. The potenial for this pump is driven by using a basolateral bicarbonate/chloride exchanger, which pumps chloride into the cell in exchange for bicarbonate. The bicarbonate then increases in plasma and facilitates buffer the acidosis. So the corrective reaction is a metabolic alkalosis (loss of a chloride containing acid, both NH4Cl or NH3 + HCl).