Question

Match each method validation term to its definition.

Precision

Detection limit

Range

Specificity

Quantitation Limit

Accuracy

Robustness

Linearity

The smallest quantity of analyte that can be distinguished from the blank.

A measure of how well plotted data follows a straight line, indicating the response is proportional to the amount of analyte in the sample.

Concentration interval over which linearity, accuracy, and precision meet specifications.

A measure of how well replicate measurements agree with each other.

The ability of a method to differentiate the analyte from the rest of the sample.

The ability of a method to be unaffected by small, purposeful changes in operational parameters.

The smallest amount of analyte that can be reliably measured.

A measure of how close a measured value is to the \"true\" value.

Answer 1

Precision- A measure of how well replicate measurements agree with each other.

Detection limit- The smallest quantity of analyte that can be distinguished from the blank.

Range- Concentration interval over which linearity, accuracy, and precision meet specifications.

Specificity-The ability of a method to differentiate the analyte from the rest of the sample.

Quantitation Limit- The smallest amount of analyte that can be reliably measured.

Accuracy- A measure of how close a measured value is to the \"true\" value.

Robustness- The ability of a method to be unaffected by small, purposeful changes in operational parameters.

Linearity- A measure of how well plotted data follows a straight line, indicating the response is proportional to the amount of analyte in the sample.