Question

write 2 paragraphs about the hematological mechanism of the liver with 2 refernces in apa format

Answer 1

The liver can be regarded as an important site of metabolism in the body.Liver plays various roles in maintaining chemical homoeostasis in the body. Liver plays a central role in haemopoiesis and synthesis of coagulation proteins (Holborow et al., 1963). The liver disease areassociated with various haematological abnormalities (Weeder et al., 2014). Anaemia arises due to multiple mechanisms viz. disturbance in gram metabolism, RBCs assimilation, and alteration in platelet function (in association with spleen).(Par et al., 2000)

The disturbance in blood coagulation due to altered metabolism of Vitamin K is alsoobserved. The process of coagulation is altered as a result of changes in vitamin K levels. A decrease in synthesis of other clotting factors, dedecrement in platelets and alteration in bleeding time are some of the factors associated with liver diseases (Lechner et al., 1977).

These conditions increase the risk of morbidity and morya liye in patient with liver diseases.

References

Holborow, E. J., Asherson, G. L., Johnson, G. D., Barnes, R. D. S., & Carmichael, D. S. (1963). Antinuclear factor and other antibodies in blood and liver diseases. British medical journal, 1(5331), 656.

Lechner, K., Niessner, H., & Thaler, E. (1977). Coagulation abnormalities in liver disease. In Seminars in thrombosis and hemostasis.4, 40-56.

Par, A., Roth, E., Rumi Jr, G., Kovacs, Z., Nemes, J., & Mozsik, G. (2000). Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C. Orvosi Hetilap, 141(30), 1655.

Weeder, P. D., Porte, R. J., & Lisman, T. (2014). Hemostasis in liver disease: implications of new concepts for perioperative management. Transfusion medicine reviews, 28(3), 107-113.