Question
In: Statistics and Probability
In a clinical trial, 50 patients who received a new medication are randomly selected. It was...
In a clinical trial, 50 patients who received a new medication are randomly selected. It was found that 10 of them suffered serious side effects from this new medication. Let p denote the population proportion of patients suffered serious side effects from this new medication.
Find the minimum sample size needed to estimate the population proportion p with 90% confidence such that the estimate is accurate within 0.04 of p.
Solutions
Expert Solution
sample proportion , p̂ =10/50 = 0.2
sampling error , E = 0.04
Confidence Level , CL= 0.90
alpha = 1-CL = 0.10
Z value = Zα/2 = 1.645 [excel
formula =normsinv(α/2)]
Sample Size,n = (Z / E)² * p̂ * (1-p̂) = (
1.645 / 0.04 ) ² *
0.20 * ( 1 - 0.20 ) =
270.55
so,Sample Size required=
271
orchestra answered 1 year agoRelated Solutions
In a clinical trial, 50 patients who received a new medication are randomly selected. It was...
In a clinical trial, 50 patients who received a new medication
are randomly selected. It was found that 10 of them suffered
serious side effects from this new medication. let p denote the
population proportion of patients suffered serious side effects
from this new medication. The 90% confidence interval for p is
about
A clinical trial is run to evaluate the efficacy of a new medication to relieve pain...
A clinical trial is
run to evaluate the efficacy of a new medication to relieve pain in
patients undergoing total knee replacement surgery. In the trial,
patients are randomly assigned to receive either the new medication
or the standard medication. After receiving the assigned
medication, patients are asked to report their pain on a scale of
0-100 with higher scores indicative of more pain. Data on the
primary outcome are shown below.
Sample Size
Mean Pain Score
Standard Deviation of...
You are designing a randomized clinical trial of a new anti-hypertensive medication. The goal is to...
You are designing a
randomized clinical trial of a new anti-hypertensive medication.
The goal is to lower the incidence of stroke, but a surrogate
endpoint will be used instead of stroke as the primary endpoint of
the trial.
(1) Give an example of
a surrogate endpoint that makes sense for the context of this
clinical trial.
(2) In the context of
this trial, give a rationale for why an investigator might decide
to use a surrogate endpoint.
The drug ancrod was tested in a double-blind clinical trial in which stroke patients were randomly...
The drug ancrod was tested in a double-blind clinical trial in
which stroke patients were randomly assigned to receive either
ancrod or a placebo. One of the response variables in the study was
whether or not the subjects experienced intracranial hemorrhaging.
Of the 84 patients who received ancrod, 13 hemorrhaged. Of the 77
patients who received the placebo, only three hemorrhaged.
a.Is there a significant difference in hemorrhaging rates
between treatments? Show your work and include all steps for full...
A clinical trial is conducted to test a new medication designed to lower systolic blood pressure...
A clinical trial is conducted to test a new medication designed
to lower systolic blood pressure (SBP). Participants are randomly
assigned to receive the new medication or a placebo. The outcome is
clinically significant SBP reduction after 30 days. The data are
shown below. Compute the totals.
Significant Reduction in SBP
No Significant Reduction in SBP
Total
New Medication
44
76
Placebo
21
99
Total
Compute the proportion of participants who experienced a
significant reduction in SBP, given they received...
Patients in a clinical trial for a new cancer treatment are classified as permanently cured, in remission
Patients in a clinical trial for a new cancer treatment are classified as permanently cured, in remission (the cancer is present, but not growing), sick (the cancer is growing), or deceased. After one year of treatment, 1/3 of sick patients go into remission, another 1/3 are permanently cured, and, unfortunately, 1/3 are deceased. Patients in remission also receive treatment after a year of which 1/4 remain in remission, 1/2 are permanently cured, and 1/4 decline to the sick condition (a) Formulate...
Researchers conducting a clinical trial randomly assigned 60 patients with painful knee osteoarthritis evenly into one...
Researchers conducting a clinical
trial randomly assigned 60 patients with painful knee
osteoarthritis evenly into one of three treatment groups:
glucosamine, chondroitin, or placebo.After the study period,
patients were asked if they experienced substantial improvement in
pain and ability to function normally.Thirty-four patients replied
that they did have an improvement, including 13 in the glucosamine
group, 16 in the chondroitin group, and 5 in the placebo group.
List a potential confounding variable
for this study and briefly explain a possible...
A clinical trial evaluates a new compound designed to improve wound healing in trauma patients. The...
A clinical trial evaluates a new compound designed to improve
wound healing in trauma patients. The new compound is compared
against a placebo. After treatment for 5 days with the new compound
or placebo, the extent of wound healing is measured. See chart
below: Wound Healing by Treatment
Percent of Wound Healing
Treatment 0-25 26-50 51-75 76-100
New Compound (n=125) 15 37 32 41
Placebo (n=125) 36 45 34 10
Is there a difference in the extent of wound healing...
A clinical trial evaluates a new compound designed to improve wound healing in trauma patients. The...
A clinical trial evaluates a new compound designed to improve
wound healing in trauma patients. The new compound is compared
against a placebo. After treatment for 5 days with the new compound
or placebo, the extent of wound healing is measured and the data
are shown in table 7-51. Is there a difference in the extent of
wound healing by treatment? Run the appropriate test at a 5% level
of significance. (Hint : Are treatment and the percent of wound...
In a trial of 300 patients who received 10-mg doses of a drug daily, 54 reported...
In a trial of 300 patients who received 10-mg doses of a drug
daily, 54 reported headaches as a side effect. Construct a 99%
confidence interval for the population proportion of patients who
receive the drug and report headache as a side effect.
ADVERTISEMENT
ADVERTISEMENT
Latest Questions
- Young and Company claims that its pressurized diving bell will, on average, maintain its integrity to...
- 1) Alternative compiled code sequence using instructions in classes A, B, C. What is the average...
- An asset is purchased on January 1 for $48,700. It is expected to have a useful...
- Do we have any online or offline tool to convert c and cpp programs into MIPS...
- -what is the pH of HCl 0,1M and NaCl 0,1M mixed together solution? -What is the...
- function X=extractDWT(x_train,startS,endS,wStep,wRange) % x_train = input signal % startS = from second % endS = end...
- Do you agree that Social Loafing is similar to Theory X. Give an example to support...
ADVERTISEMENT