Briefly describe the mechanism and signaling cascade involved in the class of GPCRs which utilize Ca2+...

Briefly describe the mechanism and signaling cascade involved in the class of GPCRs which utilize Ca²⁺ as a second messenger

Expert Solution

Phospholipase C is the perfect example for given question

G-Protein Coupled Receptor contain G protein with 7 transmembrane domains, embedded into the plasma membrane. G protein has three subunits present at the c terminal of G protein inside cell cytoplasm.
the subunit is a GTPase which shuffle from G-GTP the active form to G-GDP, inactive form. during active form subunit dissociates. The G subunit further activates PLC (Phospho Lipase C enzyme) which breaks PIP2 (phosphoinositodyl-4,5 bisphosphate) into IP3 (inositol-4,5,6- triphosphate) and DAG (di-acyl glycerol). both IP3 and DAG are secondary messenger.
DAG gets incorporated into the plasma membrane whereas IP3 goes to mitochondria and opens channel for Ca+2.
Ca=2 is released in large amound and acts as second messenger which further targets the release of proteins like Protein kinase, Phosphatase etc.

gladiator answered 3 years ago

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