Question

What human tissues are affected by malaria? What are the main clinical manifestations of the disease?

Answer 1

Malaria affects LIVER , RBC and BRAIN tissue in human body.

The manifestation of uncomplicated disease are the following:

• Fever
• Chills
• Headache
• Dizziness
• Back Pain
• Myalgia, joint and bone pains
• Cough and chest pain
• Weakness
• Nausea,vomiting,diarrhea

The typical but infrequently observed malaria attack consists of three stages:

1. Cold stage: characterised by feeling of cold and shivering followed by whole body shaking that lasts 15-60 minutes, cold, dry and pale skin.
2. Hot stage: high fever upto 40-41 degrees that lasts 2-6 hours , severe headache, palpitations,tachypnea, flushed and dry skin
3. Sweating stage: profuse sweating for 2-4hours , feeling of exhaustion.

The clinical mainfestations of severe complicated malaria:

1. Prostration
2. Hyperpyrexia
3. Dehydration'
4. Hypotension
5. Circulatory collapse
6. Electrolyte imbalances
7. Hypoglycemia
8. Severe anaemia
9. Spontaneous bleeding
10. Jaundice
11. Hepatosplenomegaly
12. Generalized convulsions
13. Coma
14. Acidosis
15. Acute abdominal pain
16. Pulmonary edema
17. Renal failure
18. Acute respiratory distress syndrome