Question

Write a detailed essay on lisinopril.

Answer 1

Lisinopril

It is a drug that belongs to angiotensin converting enzyme inhibitor.

Mechanism of action

Lisinopril blocks angiotensin converting enzyme which converts angiotensin 1 to angiotensin 2 in the resin angiotensin activating system. Angiotensin 2 is a potent vasoconstrictor and increases aldosterone release. Both angiotensin 2 and aldosterone increase blood pressure. So by blocking angiotensin converting enzyme , angiotensin 2 and aldosterone is not formed . Therefore decreased blood pressure.

Pharmokinetics

Absorption - bioavailability is 25%. Peak effect is 4 to 8 hours. Food doesn't affect its absorption.

Distribution- it doesn't bind to proteins.

Metabolism- only ace inhibitor which has no liver metabolism.

Elimination - it is eliminated unchanged in the urine.

Side effects

Cough, headache, hyperkalemia, fatigue, diarrhea.

Contraindications

It is contraindicated in history of angioedema.

Medical uses

High blood pressure, congestive heart failure, diabetic nephropathy.