Question

Explain how acute exercise would challenge the delivery of oxygen and release of carbon dioxide as well as how acute exercise may actually enhance the delivery and release of oxygen at the tissues via an explanation of shifting of the oxyhemoglobin dissociation curve, etc. Make sure to include information about hemoglobin and myoglobin structure and a full explanation of the sigmoidal shape of the dissociation curve (i.e. loading and unloading portions).

Answer 1

Acute exercise will lead to increased blood supply and oxygen utilisation by muscle and release more Carbon dioxide. Exercise will also lead to lactic acid formation which will lead to decrased pH. Increased CO2 and Low pH favours the delivery of oxygen by shifting the oxygen dissociation curve to right.

Also Increased blood flow Increases temperature that also shift thr oxygen dissociation curve to right.

Hemoglobin contains four heme units each each globular protein sub-unit. Myiglobin containsonly one heme unit a single globular protein, containing seven α-helical and six non helical segments of 153 amino acids .

Oxygen haemoglobin dissociation curve- it tells the avidity with which the oxygen is bound to the Haemoglobin. It is a sigmoid curve with platue. A shift of this curve to right means more oxygen delivery due to loose bonding with Haemoglobin. Right shift is cuase due to Decrease pH, Increased CO2, Increased Temperature and Increased 2,3 BPG.